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    Azithromycin should not be used in patients with pneumonia who are judged to be inappropriate for oral therapy because of moderate to severe illness or risk factors. (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZITHROMAX (azithromycin) and other antibacterial drugs, ZITHROMAX (azithromycin) should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. (1.4) ZITHROMAX (azithromycin) is a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Recommended dosages and durations of therapy in adult and pediatric patient populations vary in these indications. To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZITHROMAX (azithromycin) and other antibacterial drugs, ZITHROMAX (azithromycin) should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. After mixing, store suspension at 5° to 30°C (41° to 86°F) and use within 10 days. ZITHROMAX 250 mg tablets are supplied as pink modified capsular shaped, engraved, film-coated tablets containing azithromycin dihydrate equivalent to 250 mg of azithromycin. JAMAJAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Wildfeuer ALaufen HLeitold MZimmermann T Comparison of the pharmacokinetics of three-day and five-day regimens of azithromycin in plasma and urine. 1993;31(suppl E)51- 56Google Scholar Crossref Dawson CRSchachter JSallam SSheta ARubinstein RAWashton H A comparison of oral azithromycin with topical oxytetracycline/polymyxin for the treatment of trachoma in children. 1997;24363- 368Google Scholar Crossref Shepard RMDuthu GSFerraina RAMullins MA High-performance liquid chromatographic assay with electrochemical detection for azithromycin in serum and tissues. 1991;565321- 337Google Scholar Crossref Riedel KDWildfeuer ALaufen HZimmermann T Equivalence of a high-performance liquid chromatographic assay and a bioassay of azithromycin in human serum samples. 1992;576358- 362Google Scholar Crossref Shepard RMWeidler DJGarg DC et al. Human pharmacokinetics of azithromycin (CP-62,993/XZ-450): a new macrolide with an extended half-life and high tissue penetration [abstract]. Programs and abstracts of the 27th Interscience Conference on Antimicrobial Agents and Chemotherapy October 1987 New York, NY. Slaney LChubb HRonald ABrunham R In-vitro activity of azithromycin, erythromycin, ciprofloxacin and norfloxacin against Neisseria gonorrhoeae, Haemophilus ducrey'i and Chlamydia trachomatis. 1990;25(suppl A)1- 5Google Scholar Crossref Li ZHancock REW Mechanism of uptake of the dibasic macrolide antibiotic azithromycin across the outer membrane of Escherichia coli [abstract]. Proceedings of the 6th International Congress of Infectious Diseases July 19-21, 1990 Montreal, Quebec.

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