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Each year in the United States, 600,000 to 800,000 heart stents are placed to restore blood flow through coronary arteries. Patients are then given medication to keep blood clots from forming near the surgical site. “The current standard of care after angioplasty is to prescribe clopidogrel for one year, regardless of a person’s individual genotype, even though we have known for several years that variation in the CYP2C19 gene may diminish the benefit from the drug,” says Naveen Pereira, M. D., Mayo Clinic Cardiologist) “And so one-third of patients, and up to 50 percent of Asians, have this genetic variance where this enzyme doesn’t work well. Such clots can be deadly, causing heart attack and stroke. D., a Mayo Clinic cardiologist and principal investigator. And so if this enzyme doesn’t work well, what happens is the inactive drug of clopidogrel, or Plavix, is not converted to the active drug.” Alternative antiplatelet medications are sometimes far more costly and carry potentially risky side effects. It's an issue that's prompted some professional cardiovascular societies and many working cardiologists to question the U. Food and Drug Administration’s recent recommendation that patients undergo genetic testing before taking Plavix (clopidogrel bisulfate). D., Mayo Clinic Cardiologist) ”So what we are seeking is trying to figure out which patients will respond to the best type of antiplatelet drugs to prevent them from having problems after they have a stent placed.” The Tailored Antiplatelet Therapy to Lessen Outcomes after Percutaneous Coronary Intervention (TAILOR-PCI) Study, is the first prospective, randomized, scientific study to address this issue and was launched this summer by the Center for Individualized Medicine and the Division of Cardiovascular Diseases at Mayo Clinic. The two-year study of Plavix and Brilinta will include approximately 5,300 patients from 15 hospitals worldwide. Beyond answers regarding antiplatelet medications, researchers expect to gather a wealth of information about how our genes affect our heart health. Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease). It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent). Read the Medication Guide provided by your pharmacist before you start taking clopidogrel and each time you get a refill. Clopidogrel works by blocking platelets from sticking together and prevents them from forming harmful clots. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once daily. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. The dosage and length of treatment are based on your medical condition and response to treatment. 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Side effects of sugar substitutes. sugar substitutes are thought by many to be healthier and safer for you than sugar. this is not the case. sugarArtificial sweetener side effects. apr 06, 2016. overview of artificial sweeteners. equal and nutrasweet aspartame and splenda sucralose are being used as.