While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I was on this hydroxychloroquine for 6 months and then suddenly developed severe itching (burning like sensation, worse than any itch I have ever had) and rash that went from my neck to my feet. Chloroquine trpa1 itch Rogaine for plaquenil hair loss I thought fatigue is one of the symptoms of RA, so taking the right medication should help lessen fatigue, shouldn't it? When I was diagnosed with RA 2.5 years ago, I experienced fatigue and really bad pain on my foot, but since I started Plaquenil and Orencia 2 years ago, I have been in medically induced remission and don't have fatigue anymore. Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. The Plaquenil sadly didn't reduce or help my fatigue It did help with mouthsores and my rashes although. I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. Hi everyone, I am wondering if anyone has had a problem with fatigue while on Plaquenil. At first, I was nauseous for a week or so, which the dr. After the nausea went away it seemed like my pain got worse for a week or so, and then it gradually got better. I am also bothered with stomach cramps and mild diarrhea. How does plaquenil help with fatigue Hydroxychloroquine Plaquenil, Is extreme fatigue a side effect of Plaquenil? Plaquenil induced hyperpigmentation Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Did Plaquenil help your fatigue? - Sjogren's World. Things that Changed My Life with Lupus Fatigue, Part 3. Its suppose to help with fatigue and joint pain, and has slight blood thinning properties. May be worth looking at what brand you are taking. Some of us get on better with certain suppliers. Last August I decided to retire due to fatigue and joint pain. Plaquenil does relieve much of the fatigue. As for the joint pain, still a problem. Yes, depression is an issue, still is. The form of meditation I practice is called Mindfulness Based Stress Reduction and daily practicing helps relieve the symptoms of depression. Also called Plaquenil, hydroxychloroquine is a disease-modifying drug that can help decrease both the swelling and pain of rheumatoid arthritis. According to Rheumatology.org, there is not a clear reason why hydroxychloroquine is so effective in treating autoimmune diseases. It is potentially because the drug interferes with the immune system’s cells’ communications.