There’s no cure for arthritis, which is unfortunate, but feeling better is definitely possible. The progression of RA may be diminished in severity and duration by the combination of medicines and therapy that work best as determined by you and your physician. When should you take plaquenil Chloroquine g6pd onset Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate. Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate. Benefits Hydroxychloroquine is a relatively safe medicine that is used to treat mild rheumatoid arthritis. It is also used for complications of lupus. Risks Hydroxychloroquine has few side effects, but nausea and diarrhea may occur when you first start taking the drug. In very rare cases, vision loss has happened. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination therapy with other DMARDs for moderate to severe disease. A Bit of History The origin of antimalarials dates back to the 1630s in Peru. Being able to stop joint damage can lessen pain and mean a better quality of life. You can also put off joint damage, and in some cases, you can do more than just slow it down. Methotrexate and hydroxychloroquine for rheumatoid arthritis Combination therapy with methotrexate and hydroxychloroquine., DMARDs Arthritis Foundation Hydroxychloroquine diabetes medscapeChloroquine resistance and malariaUses for hydroxychloroquinePlaquenil eye painVisual field for plaquenil Plaquenil hydroxychloroquine and Rheumatrex and Trexall methotrexate are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Rheumatrex and Trexall are also used to treat some cancers and severe skin diseases such as severe psoriasis. Plaquenil vs. Rheumatrex, Trexall Prescription Treatment.. Taking Plaquenil for Rheumatoid Arthritis. Does anyone take methotrexate and hydroxychloroquine.. Methotrexate is one of the most effective medications to treat rheumatoid arthritis RA. It's the first drug most doctors prescribe after you’re diagnosed. It will help ease symptoms like joint pain, fatigue, redness, and swelling. It may also help prevent damage to your organs and joints. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Rheumatoid Arthritis Support Group. Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction.