Primaquine kills the liver stages, known as hypnozoites, of these forms of malaria, preventing relapse of infection later on. However, primaquine is known to cause severe haemolytic anaemia in people who are G6PD deficient. What to expect when taking plaquenil Plaquenil for joint pain in oeds Background/Purpose Hydroxychloroquine HCQ is frequently used to treat autoimmune diseases. The HCQ package insert and online drug information resources report an increased risk of hemolytic anemia in patients with G6PD deficiency. However, no published studies quantify this potential risk. Drug names in RED are of high risk to all deficiency variants. Names in GREEN are of low risk. G6PD deficiency is the most common metabolic disorder of red cells, affecting over 400 million people worldwide 13. The gene is X-linked so deficiency is more common in boys, though it can also occur in girls. G6PD deficiency provides protection against malaria so tends to be more common in malaria-endemic areas. Patients with severe G6PD deficiency should not take primaquine; unfortunately at this stage there are no alternative drug regimens available. G6PD deficiency is restricted to certain populations or segments of populations; therefore it may be that not every person requiring primaquine will be tested for their G6PD status, only those considered high risk for potential deficiency. Is chloroquine safe for g6pd deficiency G6PD Deficiency What You Need to Know if you are Pregnant., Drugs Official List - Does plaquenil interact with migreliefHydroxychloroquine systemic sclerosis However, it has hemolytic effects, especially in people with glucose-6-phosphate dehydrogenase deficiency G6PD, in which primaquine as a stressor to the erythrocyte induces hemolysis. Hemolysis induced by primaquine can result in discoloration of urine and faeces and it is dose related 8, 9. Side Effects of Chloroquine and Primaquine and Symptom.. Glucose 6 Phosphate Dehydrogenase Deficiency - an overview.. Who should not take Chloroquine Phosphate? - WebMD. Only 4% of patients were G6PD deficient, all of which were African American. Overall, there were no incidents of hemolysis reported in over 700 months of HCQ exposure among the 11 G6PD-deficient patients. Two G6PD-deficient patients experienced hemolysis during severe lupus flares that occurred while not taking HCQ. Brewer GJ, Zarafonetis CJ. The haemolytic effect of various regimens of primaquine with chloroquine in American Negroes with G6PD deficiency and the lack of an effect of various antimalarial suppressive agents on erythrocyte metabolism. Bull World Health Organ 1967; 3. If primaquoine phosphate is used, CDC recommends a dose of 30 mg base by mouth daily for 14 days. Because both tafenoquine and primaquine can cause hemolytic anemia in persons with glucose-6-phosphate-dehydrogenase G6PD deficiency, persons must be screened for G6PD deficiency prior to starting these drugs.