Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine for leg cramps Chloroquine pronounce Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. What are some other side effects of Plaquenil? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away Dizziness. Headache. Feeling nervous and excitable. Not hungry. Hydroxychloroquine Side Effects Get emergency medical help if you have signs of an allergic reaction hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects constipation Will you have Constipation with Plaquenil - eHealthMe, Plaquenil Indications, Side Effects, Warnings - Chloroquin function in lysosome Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Taking Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Get medical help right away if you have any very serious side effects, including chest pain, fast/irregular heartbeat, severe dizziness, fainting, seizures. A very serious allergic reaction to. Plaquenil “ Side Effects Severe abdominal pain, bloating, constipation. Increased leg spasms @ night. Hair loss, accelerated depression. At the 4th week, itchy, red dots appear along with scalp itching. ” The benefits of Plaq take from 2 - 6 months. However the side effects / stomach issues join the party right at the start. From day 1 or 2 this med made me, well, kinda queasy. I was not nauseous, but I was not interested in eating. Then the real fun began -- massive gas, and oh yeah the diarrhea. Imodium AD was the way I got through the day.