It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine and receptor mediated endocytosis Plaquenil not working anymore for lupus Get exam ASAP. Plaquenil hydroxychloroquine can cause some loss in appetite, but 30 pounds in three months is extreme and needs a thorough doctor will help and may also advise stopping it temporarily. I have been on plaquenil for many a year, and it has not affected my weight at all. If you go to or rxlist.com, neither of them list weight gain as a side effect, while they both list "nausea, vomiting, stomach pain; loss of appetite, weight loss" as side effects. Hi Jen, This is a good question. Like Hippi, my appetite fluctuates. I think alot of it has to do with Lupus and the meds as well. I hope your doctor can give you something to help you especially if your loosing alot of weight or not getting the proper nutrition. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil appetite loss Little appetite with plaquenil?" Lupus Community - Support., Weight gain while on Plaquenil? lupus Does hydroxychloroquine cause lymphomaChloroquine lentivirus productionChloroquine eea1Chloroquine phosphate amazonChloroquine phosphate abd goby I've been on Plaquenil for only 3 weeks, and it seems this whole last 3rd week, I have had NO desire for. Sometimes loss of appetite is part of a flare. Has plaquenil affected your appetite or mood. MyLupusTeam. Lupus and Appetite -. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil caused a loss of appitite and weight loss for me. Both times I started taking it, the first time it was so serious I had to stop taking it. Started again several years later when I flared again and had loss of appitite and weight loss but a bit more moderate. I've been taking Plaquenil for SLE for about 3 weeks- and all of a sudden my appetite has disappeared!