Effects of chloroquine on the liver

Discussion in 'Northwest Pharmaceuticals Canada' started by nightvi, 27-Feb-2020.

  1. wolflen XenForo Moderator

    Effects of chloroquine on the liver


    Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

    Hydroxychloroquine sulfate classification Plaquenil retinal toxicity

    SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Jan 05, 2020 Chloroquine was originally used as an anti-malarial therapeutic. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Its toxic effects on the retina are seen in the macula. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. Chloroquine is not associated with serum enzyme elevations and is an extremely rare cause of clinically apparent acute liver injury.

    Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

    Effects of chloroquine on the liver

    Hydroxychloroquine Uses, Dosage & Side Effects -, Hydroxychloroquine toxicity - EyeWiki

  2. Chloroquine malaria prophylaxis
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  5. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

    • Chloroquine Oral Route Side Effects - Mayo Clinic.
    • Chloroquine - LiverTox - NCBI Bookshelf.
    • Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs.

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Effect of Chloroquine and Artesunate on Pathology in the Liver. haemosiderosis and hemozoin were observed in the liver. The effect of Artesunate at reducing the pathologies caused by the malaria parasite was more noticeable compared to that of Chloroquine. Some side effects of chloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

     
  6. pingZero New Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Treating Rheumatoid Arthritis With Disease-Modifying Drugs. RA and Hydroxychloroquine How Effective is it for Rheumatoid. Rheumatoid arthritis - Diagnosis and treatment - Mayo Clinic
     
  7. Mr_Kryl Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Long-Term Side Effects of Plaquenil for Rheumatoid. Chloroquine Assessment of Long-Term Health Effects of. Chemists expose side effects of antimalarial drug -- ScienceDaily
     
  8. SaintFear XenForo Moderator

    Chloroquine C18H26ClN3 - PubChem In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug. In this study, the terminal half-life of chloroquine was 3.1 hr after a single 250 mg oral dose, 42.9 hr after a single 500 mg oral dose.

    Chloroquine phosphate 150 mg, hydroxychloroquine 800mg uses.
     
  9. ama Guest

    Chloroquine impairs visual transduction via modulation of. Chloroquine, which has been used in the treatment of malaria, rheumatoid arthritis and systemic lupus erythematosus, has been shown to be toxic to the retina. However, the underlying mechanisms remain unclear. In this study, we investigated the role of chloroquine in phototransduction by measuring the electroretinogram ERG.

    EFFECT OF CHLOROQUINE ON TRANSDUCTION OF CELL LINES AND.