Treatment of porphyria cutanea tarda with chloroquine

Discussion in 'Hydroxychloroquine' started by mdt, 14-Mar-2020.

  1. Dark Sniper Moderator

    Treatment of porphyria cutanea tarda with chloroquine


    Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT.

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    Kordac V, Semradova M. Treatment of porphyria cutanea tarda with chloroquine. Br J Dermatol. 1974 Jan. 90195-100. Battle AM, Stella AM, De Kaminsky AR, Kaminsky C, Mariano HG. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine. If you have cutaneous porphyria, your treatment will depend on the specific type of the disease you have and how severe your symptoms are. If you have porphyria cutanea tarda, your treatment might include Regular removal of your blood to lower the amount of iron in your liver. This is called phlebotomy. Porphyria cutanea tarda, the most common type of porphyria worldwide, is caused by a deficiency of uroporphyrinogen decarboxylase, a crucial enzyme in heme biosynthesis, which results in an accumulation of photosensitive byproducts, such as uroporphyrinogen, which leads to the fragility and blistering of sun-exposed skin.

    Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT".

    Treatment of porphyria cutanea tarda with chloroquine

    Porphyria cutanea tarda - Approach BMJ Best Practice, Porphyria Types, Symptoms, Causes, and Treatment

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  7. Chloroquine treatment can induce porphyria attacks within the first couple of months of treatment due to the mass mobilization of porphyrins from the liver into the blood stream. Complete remission can be seen within 6–12 months as each dose of antimalarial can only remove a finite amount of porphyrins and there are generally decades of accumulation to be cleared.

    • Porphyria cutanea tarda - Wikipedia.
    • Porphyria cutanea tarda a case report Journal of Medical..
    • Treatment of porphyria cutanea tarda with chloroquine and..

    In 59 patients showing clear clinical and biochemical signs of porphyria cutanea tarda PCT, we tested 3 different modes of therapy 20 patients received combined treatment with repeated bleeding and chloroquine, 24 patients were exclusively treated with oral chloroquine in low doses, and 15 patients underwent repeated phlebotomy only. Dec 20, 2019 Kordac V, Semradova M. Treatment of porphyria cutanea tarda with chloroquine. Br J Dermatol. 1974 Jan. 90195-100. Battle AM, Stella AM, De Kaminsky AR, Kaminsky C, Mariano HG. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine. Aug 16, 2017 Treatment of porphyria cutanea tarda can include Regular blood removal phlebotomies to reduce the amount of iron in the liver. Low doses of the antimalarial drug chloroquine or hydroxychloroquine. Avoidance of triggers. Treatment of any underlying condition such as HIV or hepatitis C.

     
  8. gastraler XenForo Moderator

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