While many of these can be grouped by anatomic location or type of toxicity, there are also individual medications with characteristic effects. In this article, we will describe several major categories of pharmacologic retinal toxicity and discuss examples of individual medications. Chloroquine pharmacokinetics Plaquenil anti inflammatory Does plaquenil cause weight loss Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Methemoglobinemia has also been reported from chloroquine toxicity, and retinal toxicity is a side-effect of long-term use. Q5. Would you decontaminate this child? Answer and interpretation. No – not yet. Decontamination should only be performed when the benefits outweigh the risks. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Both medications have been shown to bind melanin and to concentrate in the iris, ciliary body and retinal pigment epithelium, altering normal physiologic function. Chloroquine (Aralen) and hydroxychloroquine (Plaquenil) are traditional antimalarial agents now used in the treatment of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Chloroquine toxicity of retina Hydroxychloroquine And Chloroquine Screening 2016 AAO., Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum Is plaquenil safe during pregnancy Mar 15, 2019 Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Chloroquine and Hydroxychloroquine Toxicity Workup Approach.. Chloroquine retinopathy - Wikipedia. Hydroxychloroquine-related retinal toxicity Rheumatology.. In the 1940's chloroquine and related antimalarials were subjected to extensive pharmacologic and clinical investigations.1-6 However, the dosage of chloroquine required to treat an acute attack of malaria or for prolonged suppressive therapy was small in comparison to the accumulated chloroquine. Liver disease, renal insufficiency, obesity due to improper dosing, older age, and other retinal diseases increase the risk of retinal toxicity. Chloroquine may cause retinal damage by binding at the level of the retinal pigment epithelium RPE, where it accumulates and remains long after discontinuation of the drug. Interactions Chloroquine toxicity may be increased by all drugs with quinidine-like effects. Combination with hepatotoxic or dermatitis-causing medication should be avoided, as well as with heparin risk of hemorrhage and penicillamine. Eye Keratopathy and retinopathy may occur when large doses of chloroquine are used for long periods.