Those with APS make abnormal proteins called antiphospholipid autoantibodies in the blood. This causes blood to flow improperly and can lead to dangerous clotting in arteries and veins, problems for a developing fetus and pregnancy miscarriage. Allergy to plaquenil after being on it for years Plaquenil and depression and anxiety Hydroxychloroquine sulfatr interactions Does plaquenil cause breast tenderness Antiphospholipid Syndrome APS Positive antiphospholipid antibodies aPL Plan to initiate treatment with hydroxychloroquine HCQ/Plaquenil 200-400mg/daily for all but five of the control subjects Hydroxychloroquine HCQ was suggested to play a role in lowering antiphospholipid antibody titers and preventing thrombotic recurrences in patients with systemic lupus erythematosus, but few data are available in patients with primary antiphospholipid syndrome PAPS. Plaquenil Benefits Pregnant Women with Anti-Phospholipid Syndrome. reports that pregnant women with APL antibodies and who took Plaquenil HCQ or hydroxychloroquine had better pregnancy outcomes than those who did not. This study compared Group A - 31 women 51 pregnancies on HCQ. APS affects women five times more commonly than men. People with this disorder may otherwise be healthy, or they also may suffer from an underlying disease, most frequently systemic lupus erythematosus (commonly called lupus or SLE). Plaquenil for antiphospholipid syndrome Antiphospholipid syndrome - Diagnosis and treatment - Mayo., Long-term use of hydroxychloroquine reduces antiphospholipid antibodies. Apo hydroxychloroquine side effectsSide effects from stopping plaquenilNeed eye exam yearly using plaquenil The antiphospholipid aPL syndrome APS is an acquired autoimmune thrombophilic condition that is a cause of pregnancy complications attributable to placental insufficiency including recurrent pregnancy losses and other including IUGR, oligohydramnios, preeclampsia/toxemia and placental abruption. 11 aPL antibodies reduced the levels of AnxA5 on placental villous SCTs, 12 cultured BeWo trophoblasts, 13–15 and primary cultures of SCTs, 14 and reduce the anticoagulant activity of AnxA5 on. HYDROXYCHLOROQUINE REDUCES BINDING OF ANTIPHOSPHOLIPID.. Plaquenil Benefits Pregnant Women with Anti-Phospholipid.. Antiphospholipid syndrome - Diagnosis and treatment - Mayo Clinic. Does hydroxychloroquine Plaquenil have a role in the management of antiphospholipid syndrome? Hydroxychloroquine Plaquenil is an antimalarial medication, which is used to treat systemic lupus erythematosus SLE, also known as lupus. Objectives To evaluate the impact of HCQ on aPL titers, on glucose and cholesterol levels and its role in the prevention of thrombotic recurrences in Primary Antiphospholipid Syndrome PAPS. Methods Patients with PAPS, diagnosed according to 2006 Classification Criteria without any Connective Tissue Disease. The diagnosis of antiphospholipid syndrome is made by testing the blood of patients with blood clots and/or recurrent miscarriages for the presence of anti-phospholipid autoantibodies aPL. Screening is done using three kinds of tests. Tests may vary because of the differences in the aPL from patient to patient.