It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Can plaquenil cause achy joints and muscles Cost of enbrel vs plaquenil Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Examples of drugs that can cause interactions with hydroxychloroquine are listed below. This will help reduce swelling, pain, and stiffness in your joints and improve your quality of life. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Does hydroxychloroquine cause swelling of legs Plaquenil Oral Uses, Side Effects, Interactions., Plaquenil - Uses, Side Effects, Interactions - Can plaquenil reduce your spleen sizePlaquenil for energyChloroquine compatibilityHydroxychloroquine lower white blood cellsPlaquenil and discoid lupus s dosage One clue that your medication could be the cause is if you have edema on both your right and left legs or feet. Other causes of leg swelling are usually, but not always, one-sided. If swelling is not a side effect of your medication, it could be caused by a deep venous thromboembolism DVT. Medications With Puffy Legs as a Side Effect - GoodRx. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Please tell me about your swollen ankles/calves.. Many factors — varying greatly in seriousness — can cause leg swelling. Leg swelling related to fluid buildup. Leg swelling caused by the retention of fluid in leg tissues is known as peripheral edema. It can be caused by a problem with the circulatory system, the lymphatic system or the kidneys. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine - oral, Plaquenil. It can reduce skin problems in lupus and prevent swelling/pain in arthritis. psoriasismedication may infrequently cause serious sometimes permanent eye problems or muscle damage, especially if you take it for a long time.