Chloroquine peak plasma concentraion

Discussion in 'Chloroquine 150 Mg' started by alex_zorz, 13-Mar-2020.

  1. allex13 Moderator

    Chloroquine peak plasma concentraion


    The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body.

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    Plasma concentration multiple dose C Ce e kt k e e 0 1 Peak multiple dose C C e ke max 0 1 Trough multiple dose C Ce e k min ke 0 1 Average concentration steady state Cp D ss CL Oral administration Plasma concentration single dose C FDk Vd k k a ee ae kt k tea Time of maximum concentration single dose t k k kk a e ae max ln Sometimes, the term peak plasma level or maximum plasma concentration C p max, time for peak plasma level t Cp, max and area under plasma drug concentration AUC also come into pharmacokinetic consideration Fig. 2.3 The peak plasma level is the term often used for the attainment of the highest plasma level of a drug when given by other. Chloroquine was detectable in plasma within 30 min of giving the drug. Peak level was reached in 1-8 h after the first dose of 10 mg/kg and the peak concentrations ranged between 65 and 263 ng/ml. Chloroquine concentration declined slowly in plasma after stopping drug administration so that the concentration at the seventh day was 37.5% of the concentration on the third day.

    Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism.

    Chloroquine peak plasma concentraion

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  7. IUPAC definition. 'Pharmacokinetics 1 Process of the uptake of drugs by the body, the biotransformation they undergo, the distribution of the drugs and their metabolites in the tissues, and the elimination of the drugs and their metabolites from the body over a period of time.

    • Pharmacokinetics - Wikipedia.
    • Plasma chloroquine and desethylchloroquine concentrations..
    • Pharmacokinetics of chloroquine Saliva and plasma levels..

    Volume of distribution V d is a theoretic concept that relates the amount of drug in the body dose to the concentration C of drug that is measured in blood, plasma, and unbound in tissue water. Volume of distribution is the volume of fluid “apparently” required to contain the total-body amount of drug homogeneously at a concentration equal to that in plasma or blood Fig. 7-2 Since modern drug development, drug concentration assays have almost exclusively used plasma as a matrix rather than whole blood. Various theories about assay sensitivity, matrix interference, protein binding, and free drug movement have been put forth to explain why it is “best” to measure drug concentrations in plasma. Plasma concentration profiles after parenteral administration were characterized by wide fluctuations between peak and trough values. Absorption of im and sc chloroquine was rapid, with a median time to peak concentration of 30 min and a peak plasma concentration five times higher than after oral administration.

     
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