I don't know if it's just me but im feeling so much worse as though all my aches and pains have been increased & I feel like I've been run over by a tractor! I'm aware that it can take 3 months before I can feel the benefits but am I supposed to be feeling worse? Also, after the 3 months, when my body has adjusted to the tablets do you still get flares whilst on these tablets or does it stop that happening? It's probably not the hydroxy making you worse, it's probably just that your flare was on a tragectory to get worse anyway and the tablets just haven't kicked in yet. Getting out of bed with the kids in the morning is such a struggle and im getting awful stomach cramps and wind which i didnt have before. Wind is normal for some, you may find it dies down..not, see the doc. before my diagnosis I was tired,aneamic,stiff etc since the plaquenil I jus flare all the time. Plaquenil and mucinex Aao hydroxychloroquine guidelines Aug 02, 2010 However, after discontinuation, he may initially experience a "relapse" where his Sjogrens symptoms are worse than before. This too should subside over time. It doesn't matter if he goes back on Plaquenil or hydroxychoroquine. Both should suppress his immune system and make him more vulnerable to infection. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. When treating lupus or arthritis, tell your doctor if your symptoms do not improve after 6 months of treatment. Before taking this medicine. You should not use Plaquenil if you are allergic to hydroxychloroquine. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. If you are feeling that it's still too much to handle, you can go back to the doc and there may be another treatment to compliment what you're taking or maybe you need to increase the dose... Hope you start to feel the benefits soon, fingers crossed!! I have been on Plaquenil for years but a one off prescription of Quinoric made me very ill with nausea, stomach cramps and huge pain. If things don't improve goto hour doc and qote this site . got so ill they wanted me to go on chemo based drugs but I did not want that either. now they want me on a drug they use for people who gets epileptic fits to calm down the fibrio/flare pain. Some people's flares almost stop, some reduce in severity, some in frequency or both...depends on the person. it was so bad I just came off it for several months. I hate it and now cant come off it but cannot bear the fibrio type pain it has given me. Does plaquenil make an infection worse Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil Uses, Dosage & Side Effects - Cvs caremark does not cover plaquenilAre people on plaquenil immunocompromised What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Side Effects on Your Eyes and Vision. Plaquenil and Tinnitus - Sjogren's World. On plaquenil always made me feel very bad. hate it. before my diagnosis I was tired,aneamic,stiff etc since the plaquenil I jus flare all the time. it was so bad I just came off it for several months. got so ill they wanted me to go on chemo based drugs but I did not want that either. so reluctantly went back on the plaquenil. imo its made me worse. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects. Yes, plaquenil is difficult to adjust first, but after the first year of treatment and side effects, the benefits outweigh the problems. So, stick with it. In my opinion, the plaque nil is keeping the immune system regulated and the pain and other symptoms described will reduce.