Please consider using the search field or links below to navigate to the desired page on , an antimalarial drug, is traditionally used in the treatment of SLE. Does hydroxychloroquine cause weight gain How long does it take plaquenil to damage bones Plaquenil toxicity eye Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares. In vitro and in vivo studies showed a beneficial effect of hydroxychloroquine on thrombosis . Its effectiveness in treating APS has been previously questioned. Plaquenil for lupus mechanism Antimalarials in systemic lupus erythematosus benefits., Plaquenil. A medication for Lupus Chloroquine and osmotic lysisPlaquenil and acid reflux Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. Hydroxychloroquine DermNet NZ. How is plaquenil hydroxychloroquine used to treat lupus?. Mechanisms of action of hydroxychloroquine and chloroquine.. The safety and efficacy of the chronic use of hydroxychloroquine for systemic lupus erythematosus and juvenile idiopathic arthritis in children and infants have not been established. Children are especially sensitive to the 4-aminoquinoline compounds. MECHANISM OF ACTION. Plaquenil increases the pH of lysosomes and impairs complement-dependent antigen-antibody reactions. It also inhibits the chemotaxis of eosinophils and locomotion of neutrophils. SUMMARY OF EVIDENCE in development Ponticelli C et al. 2017 “Hydroxychloroquine in systemic lupus erythematosus SLE” Expert Opin Drug Saf. Feb 19, 2020 Mechanism Of Action. The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its.