Lysosomes ph and the antimalarial action of chloroquine

Discussion in 'Canadian Pharmacies' started by IWebMaster, 23-Feb-2020.

  1. Vassa Moderator

    Lysosomes ph and the antimalarial action of chloroquine


    For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture.

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    Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Chloroquine and ammonium chloride, by virtue of their basic properties, have been shown to raise endocytic and lysosomal pH and thereby interfere with normal iron metabolism in a variety of cell types, including mononuclear phagocytes. Cellular iron metabolism is of critical importance to Legionella pneumophila. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.

    “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. Their drug screen evaluated five other drugs that were not effective. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing.

    Lysosomes ph and the antimalarial action of chloroquine

    Chloroquine - FDA prescribing information, side effects., Chloroquine & Hydroxychloroquine supporting chemo.

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  4. The mode of action of chloroquine is as a weak lipophilic base where the free base passes easily through membranes 34. It accumulates in the acidic lysosome as it becomes protonated, increasing the pH of the lysosome 35, 36. Following exposure to concanamycin A, BMPR-II accumulates in the lysosome.

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    Krogstad DJ, Schlesinger PH. The basis of antimalarial action non-weak base effects of chloroquine on acid vesicle pH. Am J Trop Med Hyg. 1987 Mar; 36 2213–220. Krogstad DJ, Schlesinger PH. Acid-vesicle function, intracellular pathogens, and the action of chloroquine against Plasmodium falciparum. N Engl J Med. 1987 Aug 27; 317 9542–549. Chloroquine accumulates preferentially in lysosomes and raises intralysosomal pH, which in turn increases the permeability and volume of lysosomes. The increased intralysosomal pH produced by chloroquine analogues may not be sufficient to cause cellular damage specifically in tumour cells at therapeutically achievable concentrations. Jul 30, 2019 Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation.

     
  5. rivale User

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Plaquenil Plaquenil Indications, Side Effects, Warnings - Hydroxychloroquine Side Effects Common, Severe, Long Term -
     
  6. Dannie Well-Known Member

    Plaquenil and Quinine drug interactions - eHealthMe The study is based on hydroxychloroquine sulfate and cinchona the active ingredients of Plaquenil and Quinine, respectively, and Plaquenil and Quinine the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Dosage of drugs is not considered in the study.

    Plaquenil Uses, Dosage & Side Effects -