She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. More energy on plaquenil Plaquenil eye screening recommendations Testing for plaquenil users Chloroquine phosphate sigma Retinopathy. 1. Irreversible retinal damage has been observed in some patients who had received chloroquine. Significant risk factors for retinal damage include daily doses of chloroquine phosphate greater than 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal May 16, 2011 Retinal photograph showing classic “bull’s eye” retinopathy of hydroxychloroquine toxicity, which represents atrophy of the retinal pigment epithelium. This is a relatively late change, and good screening can detect toxicity before any bull’s eye is visible. Mar 08, 2012 The most common retinal change included a Bull’s eye or Target maculopathy in both chloroquine and hydroxychloroquine retinal toxicity. Fundiscopic photos of the changes seen in chloroquine and hydroxychloroquine retinopathy are shown in Figure 1A and C. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Retinal chloroquine retinopathy Recommendations on Screening for Chloroquine and., Hydroxychloroquine Retinopathy Still Alive and Well - The. All well and plaquenilPlaquenil lo loestrin fePlaquenil drug interaction cymbaltaPlaquenil and pms Dec 04, 2014 Retinal toxicity from HCQ, and its analog, chloroquine, has been recognized for many years.2,3 By some estimates, in the United States, there are more than 150,000 patients currently on chronic HCQ therapy. The incidence of HCQ retinopathy is very low. Hydroxychloroquine retinopathy A review of imaging. Retinal toxicity to antimalarial drugs chloroquine and.. Hydroxychloroquine retinopathy Eye. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Chloroquine is a potent drug used for the treatment of various diseases, including malaria and a range of connective tissue disorders. Chloroquine retinopathy is an important complication that may appear even years after cessation of the drug, presenting with impaired visual acuity, central vision loss and progressive damage that could result in irreversible blindness. Jun 11, 2009 Retinopathy is a well-characterized side effect of treatment and includes cotton-wool spots, intraretinal and pre-retinal hemorrhage, and macular edema See Figure 3. A wide incidence range of 18 percent to 86 percent has been reported for interferon retinopathy. 24 Signs develop within two weeks to three months of treatment onset; patients may complain of blurred vision or be entirely.