It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. Plaquenil and 5hr energy Hydroxychloroquine side effects and alcohol Oct bull ey macula ellipsoid plaquenil Chloroquine mechanism of action in sle Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number? Learn More Generic Name Chloroquine KLOR oh kwin Medically reviewed by Last updated on Aug 17, 2019. Brand names include Chloroquine FNA, Resochin, and Dawaquin. History. Its history goes back to Peru South America, where the indigenous people extracted the bark of the Cinchona trees and used the extract Chinchona officinalis to fight chills and fever in the seventeenth century. People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes. Chloroquine iupac name Chloroquine sulfate - DrugBank, Chloroquine Indications, Side Effects, Warnings - Plaquenil and dental surgery Structure, properties, spectra, suppliers and links for Chloroquine diphosphate, 50-63-5, Chloroquine Phosphate. Chloroquine diphosphate C18H32ClN3O8P2 ChemSpider. Chloroquine - Wikipedia. Hydroxychloroquine sulfate - DrugBank. Structure, properties, spectra, suppliers and links for Chloroquine Phosphate, 1446-17-9. Chloroquine. Formula C 18 H 26 ClN 3;. IUPAC Standard InChIKey. This structure is also available as a 2d Mol file; Other names 1,4-Pentanediamine, N4-. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.